有机酸是氨基酸的副产物,也是多种生化途径的中间产物。为了方便基于质谱的代谢组学研究,剑桥同位素实验室公司(CIL)研制出一系列稳定性同位素标记的有机酸混标。这些混标既包括33种有机酸的混标(MSK-OA-1)也有包含按类别划分的亚类混标(例如,酮酸混合物中有5种有机酸,MSK-OA1-1)。
稳定同位素标记有机酸混标的组成成分表。
将混标溶于1毫升溶剂中,可配置成浓度为250µM的溶液
Complete Set
MSK-OA-1 Labeled Organic Acid Mix (single vial of all 33 compounds)
Subsets
MSK-OA1-1 Labeled Keto Acid Mix
α-Ketobutyric acid, sodium salt (13C4, 98%)
α-Ketoglutaric acid, disodium salt (1,2,3,4-13C4, 99%) CP 97%
α-Ketoisocaproic acid, sodium salt (13C6, 99%)
α-Ketoisovaleric acid, sodium salt (13C5, 98%)
Sodium pyruvate (13C3, 99%)
MSK-OA2-1 Labeled Diacid Mix
Adipic acid, disodium salt (13C6, 99%)
Fumaric acid, disodium salt (13C4, 99%)
Maleic acid, disodium salt·H2O (13C4, 99%)
Malonic acid, disodium salt (13C3, 99%)
Methylmalonic acid, disodium salt (13C4, 99%)
Oxalic acid, disodium salt (1,2-13C2, 99%)
Sodium isobutyrate (13C4, 99%)
Succinic acid, disodium salt (13C4, 99%)
MSK-OA3-1 Labeled Monoacid Mix
Sodium acetate (1,2-13C2, 99%)
Sodium butyrate (13C4, 99%)
Sodium propionate (13C3, 99%)
MSK-OA4-1 Labeled Hydroxy Acid Mix
Glycolic acid, sodium salt (1,2-13C2, 99%)
Malic acid, disodium salt·H2O (13C4, 99%)
Sodium D-3-hydroxybutyrate (13C4, 99%) CP 97%
Sodium L-lactate (13C3, 98%) 20% w/w in H2O
DL 2-Hydroxyglutarate, disodium salt (13C5, 99%)
MSK-OA5-1 Labeled Aromatic Acid Mix
Hippuric acid (ring-13C6, 99%)
Homovanillic acid, sodium salt (1,2-13C2, 98-99%)
Phthalic acid, disodium salt (13C4, 99%)
Sodium benzoate (ring-13C6, 99%)
DL-Vanilmandelic acid (ring-13C6, 99%)
MSK-OA6-1 Labeled Other Acid Mix
L-Ascorbic acid (13C6, 99%)
Sodium D-gluconate (13C6, 99%)
MSK-OA7-1 Labeled Other Organic Acid Mix
trans-Aconitic acid (2,4,4’-13C3, 99%) CP 95%
Creatine (15N3, 98%)
Orotic acid, sodium salt (15N2, 98%)
Trisodium citrate, hemihydrate (1,5,6-carboxy-13C3, 99%)
Uric acid, sodium salt (15N2, 98%) CP 95%